Table 2.
The effect of ME and solvent fractions of the leaves of R. prinoides on castor oil induced gastrointestinal motility in mice.
| Group | Total length of Small intestine(cm) | Distance moved by the charcoal meal (cm) | Peristalsis index (%) | % Inhibition |
|---|---|---|---|---|
| ME | ||||
| 2%tween80,10 ml/kg | 56.00 ± 1.13 | 44.17 ± 1.33 | 79.00 ± 2.63 | --- |
| Loperamide, 3 mg/kg | 53.03 ± 1.28 | 15.17 ± 1.33*aeh | 24.52 ± 1.96*aeh | 71.18% |
| ME100 mg/kg | 53.10 ± 1.81 | 26.17 ± 2.73*a | 50.13 ± 2.43*a | 42.81% |
| ME200 mg/kg | 52.67 ± 1.17 | 23.13 ± 2.47*a | 31.03 ± 4.69*ae | 56.47% |
| ME400 mg/kg | 52.20 ± 1.05 | 17.15 ± 1.29*aeh | 26.55 ± 2.08*ae | 69.23% |
| Solvent fractions | ||||
| n-BF 100 mg/kg | 53.20 ± 0.31 | 22.05 ± 1.13*a | 49.10 ± 1.93 | 45.25% |
| n-BF 200 mg/kg | 53.25 ± 0.23 | 19.74 ± 0.51*adc | 31.50 ± 1.87*acd | 55.13% |
| n-BF 400 mg/kg | 52.50 ± 1.00 | 14.98 ± 1.09*acdf | 24.25 ± 1.00*acdf | 71.50% |
| CF 100 mg/kg | 53.30 ± 0.95 | 24.10 ± 1.40*a | 57.34 ± 0.93*a | 39.42% |
| CF 200 mg/kg | 53.57 ± 1.01 | 21.09 ± 0.84*ad | 39.01 ± 1.19*adf | 49.25% |
| CF 400 mg/kg | 53.23 ± 0.90 | 18.25 ± 1.07*acd | 28.35 ± 1.38*abc | 62.75% |
| PtEF 100 mg/kg | 53.10 ± 1.00 | 34.98 ± 1.73 | 75.24 ± 1.30 | 28.85% |
| PtEF 200 mg/kg | 53.75 ± 0.97 | 27.20 ± 1.57*a | 68.02 ± 1.29 | 38.30% |
| PtEF 400 mg/kg | 53.00 ± 0.60 | 20.10 ± 1.19*ad | 35.20 ± 1.92*ad | 57.90% |
| Loperamide, 3 mg/kg | 53.03 ± 0.50 | 13.03 ± 0.30*acdf | 22.20 ± 1.06*adf | 74.58% |
Values are expressed as Mean ± SEM (n = 6 mice in each group) and analyzed by one way ANOVA followed by Post Hoc Tuckey test; a compared with 2% tween 80, b compared with 100 mg/kg n-BF, c compared with 100 mg/kg CF; d compared with 100 mg/kg PtEF; f compared with 200 mg/kg PtEF; e compared with 100 mg/kg MF; h compared with 200 mg/kg MF; * = p˂0.01; ME = absolute methanol crude leave extract of Rhamnus prinoides.