Table 3.
The effect of ME and solvent fractions of the leaves of R. prinoides on castor oil induced entropooling in mice.
| Group | Mean-weight of small intestinal content (gm) | % inhibition | Mean-volume of small intestinal content (ml) | % inhibition |
|---|---|---|---|---|
| ME | ||||
| 2%tween80, 10 ml/kg | 0.59 ± 0.04 | – | 0.49 ± 0.02 | --- |
| Loperamide, 3 mg/kg | 0.23 ± 0.06*aeh | 59.31% | 0.24 ± 0.02*aeh | 65.06% |
| ME100 mg/kg | 0.42 ± 0.06*a | 32.34% | 0.37 ± 0.01 | 27.07% |
| ME200 mg/kg | 0.35 ± 0.03*a | 40.31% | 0.29 ± 0.03a | 48.02% |
| ME400 mg/kg | 0.25 ± 0.02aeh | 56.32% | 0.21 ± 0.05*ae | 57.05% |
| Solvent fractions | ||||
| n-BF 100 mg/kg | 0.40 ± 0.01*a | 34.20% | 0.36 ± 0.00*a | 31.00% |
| n-BF 200 mg/kg | 0.38 ± 0.00*ad | 48.10% | 0.31 ± 0.01ad | 47.05% |
| n-BF 400 mg/kg | 0.26 ± 0.07acdf | 57.50% | 0.19 ± 0.00*acdf | 61.05% |
| CF 100 mg/kg | 0.44 ± 0.01*a | 34.50% | 0.41 ± 0.01*a | 26.01% |
| CF 200 mg/kg | 0.40 ± 0.00*adf | 47.20% | 0.30 ± 0.01*ad | 45.01% |
| CF 400 mg/kg | 0.29 ± 0.01adf | 52.50% | 0.20 ± 0.00*adf | 55.01% |
| PtEF 100 mg/kg | 0.53 ± 0.01 | 29.20% | 0.49 ± 0.04 | 23.06% |
| PtEF 200 mg/kg | 0.48 ± 0.02*a | 39.50% | 0.37 ± 0.01a | 44.01% |
| PtEF 400 mg/kg | 0.39 ± 0.03*ad | 46.40% | 0.228 ± 0.02*acd | 52.01% |
| Loperamide, 3 mg/kg | 0.22 ± 0.01*abcdf | 62.50% | 0.23 ± 0.01*abcdf | 66.03% |
Values are expressed as Mean ± SEM (n = 6 mice in each group) and analyzed by one way ANOVA followed by Post Hoc Tuckey test; a compared with 2% tween 80, b compared with 100 mg/kg n-BF, c compared with 100 mg/kg CF; d compared with 100 mg/kg PtEF; f compared with 200 mg/kg PtEF; e compared with 100 mg/kg MF; h compared with 200 mg/kg MF; * = p˂0.01; ME = absolute methanol crude leave extract of Rhamnus prinoides.