Table 4.
In-Vivo ADI of the ME and solvent fractions of R. prinoides.
| Test agents | Dose administered | Delay in defecation (time of onset in minute, Dfreq %) | Gut meal travel distance, (Gmeq %) | Reduction in Intestinal fluid accumulation (%) | Anti-diarrheal index (ADI) |
|---|---|---|---|---|---|
| ME | ME 100 mg/kg | 20.13% | 45.21% | 35.20% | 32.47% |
| ME 200 mg/kg | 36.11% | 50.24% | 52.23% | 43.14% | |
| ME 400 mg/kg | 52.10% | 51.27% | 55.26% | 53.24% | |
| Loperamide | 3 mg/kg | 57.69% | 62.26% | 60.06% | 63.21% |
| Solvent fractions | n-BF 100 mg/kg | 21.20% | 46.50% | 37.30% | 35.13% |
| n-BF 200 mg/kg | 38.50% | 52.20% | 54.40% | 48.24% | |
| n-BF 400 mg/kg | 64.30% | 59.40% | 62.60% | 64.40% | |
| CF 100 mg/kg | 20.10% | 45.50% | 34.30% | 31.40% | |
| CF 200 mg/kg | 35.20% | 49.50% | 50.10% | 45.20% | |
| CF 400 mg/kg | 56.40% | 53.30% | 52.26% | 57.50% | |
| PtEF 100 mg/kg | 19.50% | 40.50% | 30.10% | 27.30% | |
| PtEF 200 mg/kg | 30.20% | 47.40% | 39.20% | 36.50% | |
| PtEF 400 mg/kg | 50.25% | 48.25% | 51.30% | 52.30% | |
| Loperamide | 3 mg/kg | 67.20% | 63.50% | 62.30% | 65.90% |