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. Author manuscript; available in PMC: 2023 Dec 5.
Published in final edited form as: Angew Chem Int Ed Engl. 2022 Nov 9;61(49):e202210935. doi: 10.1002/anie.202210935

Scheme 1.

Scheme 1.

Schematic illustration showing combination cancer treatment based on engineered DNAzyme molecular machines. (Left) Dynamic intercellular regulation of T-cell/cancer cell interactions based on chain-1, chain-2 and chain-3. The distance between T-cells and cancer cells can be revealed by the fluorescence signal (TAMRA). (Right) Dynamic intracellular regulation of mitochondria aggregation in cancer cells based on chain-4 and chain-5. Here, the mitochondria aggregation only happened in zinc deficient cancer cells.