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. 2023 May 24;14:1151728. doi: 10.3389/fimmu.2023.1151728

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Copyright © 2023 Wang, Qi, Wang, Zhang and Jianguo

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The correlation between the expression of metabolites and the severity of sepsis. (A) Relative expression of sphinganine in healthy group and sepsis group. (B-F) Pearson correlation of the expression of sphinganine and APACHE-II(R=0.69, P<0.001), PCT(R=0.81, P<0.001), CRP(R=0.65, P<0.001), IL-6(R=0.64, P<0.001), WBC(R=0.73, P<0.001). (G) Relative expression of Mannose 6-phosphate in healthy group and sepsis group. (H-L) Pearson correlation of the expression of mannose-6-phosphate and and APACHE-II(R=0.80, P<0.001), CRP(R=0.63, P<0.001), IL-6(R=0.93, P<0.001), PCT(R=0.77, P<0.001), WBC(R=0.75, P<0.001). P values 0.05 (*) or P values 0.01 (**) was regarded as significant.