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. 2023 May 24;14:1151728. doi: 10.3389/fimmu.2023.1151728

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Copyright © 2023 Wang, Qi, Wang, Zhang and Jianguo

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Sphinganine alleviates sepsis-induced intestinal injury in vitro. (A) Effect of a 24 h treatment with mannose-6-phosphate (10μm) and sphinganine (10μm) on Caco-2 cell cytotoxicity, as evidenced by the LDH assay. (B) Chemical structure of sphinganine. (C) Outcome of 24 h treatments with varying sphinganine concentrations on Caco-2 cell cytotoxicity, as evidenced by the LDH assay. (D) ZO-1 and occludin protein expressions, as assessed by Western blot analysis. (E) Statistical plot of gray value of ZO-1 and Occludin were detected by Western blot. P values 0.05 (*) or 0.01 (**) was regarded as significant.