Fig. 1.

Integrative landscape of molecular alterations in biliary cancer. Landscape of molecular alterations in biliary tract cancer cohort (n=124). Each column represents a sample, identified at the bottom, each row represents a gene shown on the left, arranged according to functional groups as indicated. The bar on top displays cases with tumor mutation burden (TMB >10 mutations/Mb). Mutation types are color coded: missense (green), indels (red), nonsense (black), splice site (orange), pathogenic germline (cyan), fusion (purple), copy number deletion (blue), copy number amplification (dark red), multiple hits (grey), and promotor mutation (dark pink). Respective percentages of cases with gene aberrations are shown on the right.