Fig. 2.

Frequent genomic aberrations seen in biliary cancer. (A) Violin plots showing mutation burden across cholangiocarcinoma cohorts: TCGA-CHOL, MI-ONCOSEQ pre- and post-chemotherapy BTC cohort. The overall mutation burden is significantly higher in MI-ONCOSEQ advanced biliary tract cohort relative to the primary tumors in the TCGA cohort. (B) A summary of mutations in chromatin modifier genes in the BTC cohort. Individual samples represented in columns, genes in rows. The bar graphs on the right summarize the mutation frequency and number of samples mutated for each gene. Molecular alterations are color coded as described in Fig. 1. (C) Copy number landscape of the BTC cohort (GISTIC2, Q < 0.05), significant losses or gains with interesting genes are represented in blue and red color, respectively.