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. 2023 Jun 7;15:41. doi: 10.1186/s13073-023-01195-2

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Estimate correlation. a Correlation between RNAseq1 (TS1) and RNAseq2 (TS2)-based estimates, using MGP (top) or Bisque (bottom). Each point represents one individual. For 42 of the individuals, mRNA was extracted for different but nearby tissue samples (blue), while for seven of the individuals the RNA was extracted from the same tissue sample but sequenced twice as part of RNAseq1 and RNAseq2 datasets (yellow). Pearson’s correlation for each cell type is shown separately for estimates derived from the same and different tissue samples. b Summary table of the correlation values shown in a. c Correlation between the estimates derives using the two RNA-based estimation methods in RNAseq1 (TS1) and RNAsq2 (TS2) datasets. d Correlation between RNA-based (MGP or Bisque) and WGBS-based estimates derived from the same (RNAseq1, WGBS) or different tissue samples (RNAseq2, WGBS). RNAseq2 estimates derived from the seven resequenced samples were excluded from the analysis