Table 2.

INTEM/HEPTEM CT ratio, aPTT, and anti-Xa values for the first available ROTEM measurement after the start of unfractionated heparin (UFH) or therapeutic low molecular weight heparin (LMWH).

	UFH	No	Therapeutic LMWH	No	p-value
Days after intubation	10 [7–19]	16	8 [5–17]	82
ROTEM
INTEM CT (in s)	256 [239–286]	16	188 [175–205]	82	<0.001
INTEM CFT (in s)	58 [39–66]	16	48 [39–58]	82	0.12
INTEM MCF (in mm)	74 [70–79]	16	73 [69–77]	82	0.38
HEPTEM CT (in s)	183 [176–204]	16	184 [171–202]	82	0.73
HEPTEM CFT (in s)	46 [39–56]	16	50 [40–61]	82	0.38
HEPTEM MCF (in mm)	74 [70–78]	16	71 [67–75]	82	0.07
INTEM/HEPTEM CT ratio	1.4 [1.3–1.4]	16	1.0 [1.0–1.1]	82	<0.001
>1.1	14 (87.5%)		11 (13.4%)
≤1.1	2 (12.5%)		71 (86.6%)
INTEM/HEPTEM CFT ratio	1.2 [1.1–1.3]	16	0.97 [0.90–1.0]	82	<0.001
INTEM/HEPTEM MCF ratio	1.00 [0.99–1.01]	16	1.02 [1.01–1.04]	82	<0.001
Routine laboratory parameters
aPTT (in s)	65 [46–74]	16	30 [28–34]	76	<0.001
>50a	12 (75%)		0 (0%)
<50	4 (25%)		76 (100%)
anti-Xa (in IU/mL)	0.71 [0.58–0.86]	10	0.55 [0.44–0.74]	53	0.15
Platelet count (in 109/L)	248 [173–385]	16	317 [222–382]	78	0.384

Data are presented as mean (SD), median [IQR,] or n(%). No denotes the number of measurements.

^aBased on an aPTT heparin therapeutic range of 50–80s as applied in our hospital.