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. 2023 Jun 7;12:100140. doi: 10.1016/j.tru.2023.100140

Table 2.

INTEM/HEPTEM CT ratio, aPTT, and anti-Xa values for the first available ROTEM measurement after the start of unfractionated heparin (UFH) or therapeutic low molecular weight heparin (LMWH).

UFH No Therapeutic LMWH No p-value
Days after intubation 10 [7–19] 16 8 [5–17] 82
ROTEM
INTEM CT (in s) 256 [239–286] 16 188 [175–205] 82 <0.001
INTEM CFT (in s) 58 [39–66] 16 48 [39–58] 82 0.12
INTEM MCF (in mm) 74 [70–79] 16 73 [69–77] 82 0.38
HEPTEM CT (in s) 183 [176–204] 16 184 [171–202] 82 0.73
HEPTEM CFT (in s) 46 [39–56] 16 50 [40–61] 82 0.38
HEPTEM MCF (in mm) 74 [70–78] 16 71 [67–75] 82 0.07
INTEM/HEPTEM CT ratio 1.4 [1.3–1.4] 16 1.0 [1.0–1.1] 82 <0.001
>1.1 14 (87.5%) 11 (13.4%)
≤1.1 2 (12.5%) 71 (86.6%)
INTEM/HEPTEM CFT ratio 1.2 [1.1–1.3] 16 0.97 [0.90–1.0] 82 <0.001
INTEM/HEPTEM MCF ratio 1.00 [0.99–1.01] 16 1.02 [1.01–1.04] 82 <0.001
Routine laboratory parameters
aPTT (in s) 65 [46–74] 16 30 [28–34] 76 <0.001
>50a 12 (75%) 0 (0%)
<50 4 (25%) 76 (100%)
anti-Xa (in IU/mL) 0.71 [0.58–0.86] 10 0.55 [0.44–0.74] 53 0.15
Platelet count (in 109/L) 248 [173–385] 16 317 [222–382] 78 0.384

Data are presented as mean (SD), median [IQR,] or n(%). No denotes the number of measurements.

a

Based on an aPTT heparin therapeutic range of 50–80s as applied in our hospital.