Table 2.
INTEM/HEPTEM CT ratio, aPTT, and anti-Xa values for the first available ROTEM measurement after the start of unfractionated heparin (UFH) or therapeutic low molecular weight heparin (LMWH).
UFH | No | Therapeutic LMWH | No | p-value | |
---|---|---|---|---|---|
Days after intubation | 10 [7–19] | 16 | 8 [5–17] | 82 | |
ROTEM | |||||
INTEM CT (in s) | 256 [239–286] | 16 | 188 [175–205] | 82 | <0.001 |
INTEM CFT (in s) | 58 [39–66] | 16 | 48 [39–58] | 82 | 0.12 |
INTEM MCF (in mm) | 74 [70–79] | 16 | 73 [69–77] | 82 | 0.38 |
HEPTEM CT (in s) | 183 [176–204] | 16 | 184 [171–202] | 82 | 0.73 |
HEPTEM CFT (in s) | 46 [39–56] | 16 | 50 [40–61] | 82 | 0.38 |
HEPTEM MCF (in mm) | 74 [70–78] | 16 | 71 [67–75] | 82 | 0.07 |
INTEM/HEPTEM CT ratio | 1.4 [1.3–1.4] | 16 | 1.0 [1.0–1.1] | 82 | <0.001 |
>1.1 | 14 (87.5%) | 11 (13.4%) | |||
≤1.1 | 2 (12.5%) | 71 (86.6%) | |||
INTEM/HEPTEM CFT ratio | 1.2 [1.1–1.3] | 16 | 0.97 [0.90–1.0] | 82 | <0.001 |
INTEM/HEPTEM MCF ratio | 1.00 [0.99–1.01] | 16 | 1.02 [1.01–1.04] | 82 | <0.001 |
Routine laboratory parameters | |||||
aPTT (in s) | 65 [46–74] | 16 | 30 [28–34] | 76 | <0.001 |
>50a | 12 (75%) | 0 (0%) | |||
<50 | 4 (25%) | 76 (100%) | |||
anti-Xa (in IU/mL) | 0.71 [0.58–0.86] | 10 | 0.55 [0.44–0.74] | 53 | 0.15 |
Platelet count (in 109/L) | 248 [173–385] | 16 | 317 [222–382] | 78 | 0.384 |
Data are presented as mean (SD), median [IQR,] or n(%). No denotes the number of measurements.
Based on an aPTT heparin therapeutic range of 50–80s as applied in our hospital.