Table 4.
Associations between coagulation assays (aPTT and anti-Xa) and the INTEM/HEPTEM CT ratio and interaction with UFH/LMWH. When applicable, stratified analyses were performed on patients using UFH and LMWH separately.
| Dependent variable: INTEM/HEPTEM CT ratio | B (95% CI) | p-value |
|---|---|---|
| Independent variable: anti-Xa | ||
| Model 1 | <0.001 | |
| anti-Xa | 0.15 (0.07; 0.23) | <0.001 |
| Model 2 | <0.001 | |
| anti-Xa | 0.09 (0.04; 0.15) | <0.001 |
| UFH use (yes/no) | 0.05 (−0.06; 0.17) | 0.376 |
| Interaction anti-Xa *UFH use | 0.22 (0.07; 0.37) | 0.005 |
| Independent variable: aPTT | ||
| Model 1 | <0.001 | |
| aPTT | 0.008 (0.007; 0.009) | <0.001 |
| Model 2 | <0.001 | |
| aPTT | 0.005 (0.001; 0.008) | 0.016 |
| UFH use (yes/no) | 0.198 (0.022; 0.374) | 0.028 |
| Interaction aPTT*UFH use | 0.000 (−0.004; 0.004) | 0.91 |
| Stratified results: anti-Xa | ||
| UFH patients | 0.31 (0.001–0.62) | 0.050 |
| LMWH patients | 0.09 (0.05–0.13) | <0.001 |
Data are β regression coefficients with 95% confidence intervals and p-values. Model 1: crude. Model 2: model 1 with an interaction term.