Fig. 1.

MSC-EVs delivered IV in a mouse LPS ARDS model. LPS (1 mg kg⁻¹) was given to mice intratracheally followed by MSC-EVs IV. 24 h later BAL was performed and total protein measured by BCA assay (A), total infiltrating cells were counted by staining and haemocytometry (B) and cytokine ELISAs were performed to quantify TNF-α (C) and IL-8 (D) concentrations in BAL. Sham N = 4, Vehicle N = 8, BM-EVs N = 5, UC-EVs N = 8, 10 × UC-EVs N = 5. † p < 0.05 wrt sham. *p < 0.05 wrt LPS with vehicle