Table 3.

Reference morphometries (n = 79 subjects; one whole slide image per subject).

Reference Morphometries	Institution 1 (n=43)	Institution 2 (n=8)	Institution 3 (n=28)	Combined (N=79)
Patient Characteristics
Male sex, n (%)	29 (67.44%)	5 (62.50%)	20 (71.43%)	54 (68.35%)
Age (years)	59.16 ± 11.95	60.63 ± 13.32	53.68 ± 11.94	57.37 ± 12.25
SCr (mg/dL)	1.07 ± 0.24	0.81 ± 0.28 a	0.86 ± 0.14 a	0.97 ± 0.24
Glomerular histomorphometric
Glomeruli (per cortical mm2)	2.59 ± 0.64	1.86 ± 0.57 a	2.57 ± 0.80 b	2.51 ± 0.72
Sclerotic glomeruli (per cortical mm2)	0.19 ± 0.14	0.08 ± 0.06	0.24 ± 0.21	0.20 ± 0.17
Glomerular proportion of cortex	0.05 ± 0.01	0.04 ± 0.01	0.05 ± 0.01	0.05 ± 0.01
Average glomerular area (μm2)	18833 ± 3765	23836 ± 6113 a	19248 ± 3361 b	19487 ± 4134
Stdev. glomerular area (μm2)*	9653 ± 3879	10863 ± 2699	8451 ± 1846	9350 ± 3242
Average glomerular radius (μm)	63.8 ± 6.81	72.08 ± 10.73 a	65.93 ± 5.98	65.39 ± 7.33
Stdev. glomerular radius (μm)	17.08 ± 2.63	19.62 ± 3.74	16.88 ± 2.94	17.27 ± 2.93
Average sclerotic glomerular area (μm2)	8252 ± 1712	9222 ± 1883	7780 ± 1579	8188 ± 1713
Stdev. sclerotic glomerular area (μm2)	4159 ± 1325	5293 ± 3085	2797 ± 1319 a,b	3804 ± 1751
Average sclerotic glomerular radius (μm)	42.04 ± 4.66	44.69 ± 5.13	42.62 ± 4.68	42.51 ± 4.72
Stdev. Sclerotic glomerular radius (μm)	11.56 ± 2.03	13.03 ± 3.45	8.33 ± 3.89 a,b	10.59 ± 3.37
Glomerulosclerosis ratio	0.07 ± 0.06	0.04 ± 0.04	0.08 ± 0.07	0.07 ± 0.06
Tubular morphometrics
Tubules (per cortical mm2)	173.53 ± 34.40	132.92 ± 38.17 a	189.58 ± 50.16 b	175.10 ± 43.57
Tubular proportion of cortex	0.55 ± 0.05	0.52 ± 0.07	0.45 ± 0.09 a,b	0.51 ± 0.08
Average cortical tubular area (μm2)	3269 ± 612	4219 ± 1141 a	2476 ± 722 a,b	3084 ± 885
Stdev. cortical tubular area (μm2)	3495 ± 1002	5752 ± 3652 a	2809 ± 1232 b	3481 ± 1719
Average cortical tubular radius (μm)	20.95 ± 1.53	23.43 ± 2.39 a	17.92 ± 2.31 a,b	20.13 ± 2.62
Stdev. cortical tubular radius (μm)	7.65 ± 1.02	8.93 ± 1.67 a	7.00 ± 1.38 b	7.55 ± 1.33
Cortical glomerulus to tubule ratio	0.27 ± 0.05	0.37 ± 0.05 a	0.23 ± 0.04 a,b	0.27 ± 0.06
Vascular morphometrics	0.09 ± 0.02	0.08 ± 0.02	0.11 ± 0.02 a,b	0.09 ± 0.02
Arteries(ioles) per cortical mm2
Arter(iole) proportion of cortex	5.96 ± 1.59	4.04 ± 1.14 a	6.54 ± 1.98 b	5.97 ± 1.82
Average lumen to wall ratio	0.04 ± 0.02	0.03 ± 0.01	0.04 ± 0.02	0.04 ± 0.02

Data are represented as mean ± standard deviation, if not indicated otherwise.

^*Standard deviation for the population of glomeruli within a single case.

^aAdjusted p-value ≤ 0.05 compared to Institution 1.

^bAdjusted p-value ≤ 0.05 compared to Institution 2.

Abbreviations: SCr, serum creatinine; Stdev: standard deviation.