Table 4. Correlation of reference morphometrics to age, sex, and serum creatinine.
Women were coded with 0 and men with 1 in this study.
| Outcome (R2) | Age β (95% CI) | p | Sex β (95% CI) | p | SCr β (95% CI) | p |
|---|---|---|---|
|
| |||
|
Glomerular histomorphometric
|
|||
|
Mean glomerular area (μm2) (0.31)
|
14.2 (−164.3, 192.6) | 0.765 | 1660.1 (−306.8, 3627.1)†| 0.068 | 5874.7 (2457.2, 9292.3)*| 0.018 |
|
Mean glomerular radius (μm) (0.31)
|
0.02 (−0.32, 0.36) | 0.826 | 3.02 (−0.92, 6.97)†| 0.081 | 10.82 (3.64, 18)*| 0.023 |
|
Stdev. glomerular area (μm2) (0.09)
|
17.6 (−52, 87.2) | 0.391 | 1384.9 (672.4, 2097.5)*| 0.014 | −1106 (−1770.4, −441.5)*| 0.019 |
|
Glomerular area density (0.05)
|
0 (−0.0002, 0.0002) | 0.877 | 0.0015 (−0.0066, 0.0097) | 0.504 | −0.007 (−0.0104, −0.0036)*| 0.012 |
|
# Glomeruli per cortical cm2 (0.21)
|
0 (−0.004, 0.004) | 0.984 | −0.059 (−0.213, 0.094) | 0.237 | −0.371 (−0.648, −0.095)*| 0.029 |
|
# Sclerotic glomeruli per cortical cm2 (0.23)
|
0.0022 (−0.0019, 0.0064) | 0.146 | 0.009 (−0.0011, 0.0191)†| 0.061 | 0.0043 (−0.2268, 0.2354) | 0.943 |
|
Mean sclerosed glomerular radius (μm)(0.05)
|
0.052 (−0.203, 0.308) | 0.472 | 1.284 (−5.013, 7.581) | 0.473 | 2.95 (1.899, 4.002)*| 0.007 |
|
Glomerulosclerosis ratio (0.18)
|
0.0018 (−0.0006, 0.0041)†| 0.082 | 0.0134 (0.0021, 0.0246)*| 0.036 | 0.0339 (−0.1596, 0.2275) | 0.529 |
|
Tubular morphometrics
|
|||
|
Cortical tubular area density (0.34)
|
0.0003 (−0.0051, 0.0057) | 0.827 | −0.007 (−0.0806, 0.0665) | 0.721 | 0.0813 (−0.0286, 0.1912)†| 0.086 |
|
Mean cortical tubular area (μm2) (0.43)
|
−5.84 (−59.81, 48.13) | 0.687 | 11.24 (−1199.2, 1221.67) | 0.972 | 1020.72 (−156.15, 2197.59)†| 0.065 |
|
Mean cortical tubular radius (μm) (0.55)
|
0.007 (−0.152, 0.165) | 0.876 | 0.289 (−2.991, 3.569) | 0.741 | 2.983 (2.197, 3.77)**| 0.004 |
|
Stdev. cortical tubular radius (μm) (0.26)
|
|||
|
Mean medullary tubular radius (μm) (0.61)
|
−0.001 (−0.031, 0.03) | 0.924 | 0.04 (−0.657, 0.738) | 0.826 | 1.632 (0.014, 3.251)*| 0.049 |
|
Stdev. medullary tubular area (μm2) (0.22)
|
−10 (−27.4, 7.5) | 0.133 | 512.3 (−232.4, 1257)†| 0.098 | −436.5 (−2161.4, 1288.4) | 0.39 |
|
Mean arterial(olar) lumen to wall ratio (0.42)
|
−0.0006 (−0.0045, 0.0034) | 0.604 | −0.0261 (−0.0528, 0.0005)†| 0.052 | 0.0178 (−0.132, 0.1676) | 0.66 |
|
Vascular morphometrics
|
|||
|
Glomerulus to cortical tubule area ratio (0.31)
|
0 (−0.0006, 0.0005) | 0.754 | 0.0038 (−0.0068, 0.0145) | 0.261 | −0.0245 (−0.0398, −0.0093)*| 0.02 |
|
# Artery(ioles) per cortical cm2 (0.18)
|
0.005 (−0.001, 0.012)†| 0.062 | 0.169 (0.005, 0.333)*| 0.047 | −0.557 (−1.864, 0.75) | 0.208 |
| Cortical artery(iole) area density (0.05) | 0.0002 (0.0001, 0.0003)*| 0.009 | 0.0018 (−0.0178, 0.0213)1 0.736 | −0.0011 (−0.0209, 0.0187)1 0.834 |
Symbols/abbreviations: Stdev., standard deviation;
**
significance <0.005,
*
significance <0.05,
†
significance < 0.1, β: regression coefficient, CI: confidence interval.