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[Preprint]. 2023 May 23:2023.05.22.540829. [Version 1] doi: 10.1101/2023.05.22.540829

Fig. 2. IgG binding responses in mice immunized with monovalent SARS-CoV-2 RBD scNP vaccine, trivalent SARS-CoV-2/RsSHC014/MERS-CoV RBD scNP, and adjuvant alone.

Fig. 2.

Mouse sera was measured at pre-prime, pre-boost, and two-week post boost against the following spike antigens (A) SARS-CoV Tor2, (B) RsSHC014, (C) SARS-CoV-2, and (D) MERS-CoV. (E) Vaccine-elicited hACE2-blocking serum responses in monovalent, trivalent, and adjuvant-only vaccinated mice. (F) Vaccine-elicited hDPP4-blocking serum responses in monovalent, trivalent, and adjuvant-only vaccinated mice. (G) Cross-reactivity of monovalent, trivalent, vs adjuvant-only IgG responses against Group 1 (Canine CoV-HuPn), Group 2a (OC43), 2b (WIV-1, SARS-CoV GZ02, ZC45, GXP4L, and BANAL-236), 2c (MERS-CoV, NL140422, HKU4, and HKU5), 2d (BtKY06), and Group 4 (Porcine deltaCoV Haiti) coronavirus RBDs.