Figure 2. Broadly blocking serum Abs.

(A) Serum samples from 6 Swedish individuals were tested against 12 world-wide strains, including 9 ABO antigen-binding Generalist (G) and 3 Indigenous American Specialists (S) ¹¹. The BabA alignments and heterogenicities are shown in Figure S2C, and the strain binding characteristics are shown in Figure S2B.

(B) Phylogenetic tree with the H. pylori strains CCUG 17875 (17875/Leb, GenBank CP090367) and J166 ²² both from central/southern Europe, TIGR26695, NCTC11637, P12, HPAGA1, HUP-B14, USU101 https://www.ncbi.nlm.nih.gov/nuccore/NZ_CP032818.1, and ELS37 in the hpEurope domain (green) and their distance from the African (red and blue, including J99 of African phylogeny ⁴⁰), South Asian (black), Oceanian (turquoise), East Asian (yellow), and Indigenous American (orange) H. pylori strains.