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[Preprint]. 2023 May 25:2023.05.24.542150. [Version 1] doi: 10.1101/2023.05.24.542150

Figure 7: Evaluation of mice 5 months after femoral artery ligation and treatment with GelCad hydrogels.

Figure 7:

A) Representative image of hindlimb appearance.

B-C) Representative image and quantification of LDPI measurements. Data are presented as mean ± SD from N=2 biological replicates. The red line indicates the expected ratio for two healthy limbs.

D) Representative μCT images and corresponding vessel traces of a healthy versus ligated limb.

E) Quantification of total vessel length in the hindlimbs. To account for variance in perfusion with the MICROFIL polymer, data are presented as normalized vessel lengths for ligated versus healthy hindlimb in the same mouse. Each data point represents an individual mouse and data are presented as mean ± SD from N=2 biological replicates. The red line indicates the expected ratio for two healthy limbs.

F) Aggregated vessel diameters from the vessel trace data for healthy and ligated limbs. Each datapoint represents a single vessel (determined from branch point analyses). Data are presented as mean ± SD from N=2 biological replicates. Statistical significance was calculated by a student’s paired t-test (no significant difference).