Table 3: TWAS & Colocalization neuropsychiatric trait results.
Shared refers to the number of significant (FDR < 0.05) genes that are in common with the bulk TWAS-significant gene set, whereas unique refers to those that are not present in the bulk TWAS-significant gene set.
| Cell Type | Significant eGenes | Num Significant TWAS Genes, Shared | Num Significant TWAS Genes, Unique | Num Genes with Coloc PP4>0.8, Shared | Num Genes with Coloc PP4>0.8, Unique |
|---|---|---|---|---|---|
| B Cells Naïve | 4,009 | 90 | 43 | 43 | 13 |
| B Cells Memory | 3,571 | 142 | 58 | 62 | 25 |
| T Cells CD8 | 2,875 | 108 | 50 | 50 | 15 |
| T Cells CD4 Naïve | 3,082 | 120 | 46 | 56 | 19 |
| T Cells CD4 Memory Resting | 3,082 | 115 | 43 | 55 | 22 |
| NK Cells Resting | 3,858 | 156 | 72 | 73 | 21 |
| Monocytes | 3,483 | 126 | 52 | 62 | 24 |
| Neutrophils | 4,629 | 76 | 35 | 35 | 9 |
| Bulk | 7,302 | 906 | / | 155 | / |