TABLE I:
The demographics of the brain tumor patients along with their histological and molecular diagnoses according to the World Health Organization guidelines (mIDHI = IDH1(R132H) mutation, wtIDH = IDH1/2 wild type). The quality of the MRSI data was rated based on the quality parameters (CRLB< 20%, FWHM< 0.1 ppm, SNR> 5) from spectral fitting by LCModel. Treatment prior to MRSI scan included: PBT = proton beam therapy, IMRT = intensity modulated radiotherapy, VMAT = volumetric modulated arc therapy, SRS = stereotactic radiosurgery, TMZ = temozolomide, HU = hydroxyurea, Bev = bevacizumab. ND = Not Diagnosed by pathology, presumptive diagnosis of glioma is based on imaging features.
| Patient # | Age/Gender | Histological Diagnosis | Molecular Diagnosis | Treatment | MRSI quality | |||
|---|---|---|---|---|---|---|---|---|
| Grade | Type | IDH1 status | 1p/19q codel | Other | ||||
| 01 | 31/M | 2 | Astrocytoma | mIDHI | not-deleted | ATRX, TP53 | No treatment | Good |
| 02 | 34/F | 3 | Astrocytoma | mIDHI | not-deleted | No treatment | Good | |
| 03 | 42/F | 2 | Astrocytoma | mIDHI | not-deleted | PBT 60Gy | Good | |
| 04 | 42/M | 2 | Astrocytoma | mIDHI | not-deleted | ATRX | IMRT 60 Gy + C6-TMZ | Good |
| 05 | 51/M | 3 | Anaplastic Astrocytoma | mIDHI | not-deleted | ATRX, TP53 | Surgery, PBT 60Gy, C6-TMZ | Good |
| 06 | 66/F | 3 | Oligodendroglioma | mIDHI | deleted | TP53 | No treatment | Good |
| 07 | 33/F | 2 | Oligodendroglioma | mIDHI | not-deleted | No treatment | Bad | |
| 08 | 28/F | 2 | Oligodendroglioma | mIDHI | not-deleted | Surgery | Good | |
| 09 | 50/M | 2 | Oligodendroglioma | mIDHI | not-deleted | Surgery, XRT 60 Gy | Good | |
| 10 | 57/M | 2 | Oligodendroglioma | mIDHI | deleted | Surgery, C6-TMZ | Good | |
| 11 | 52/F | 2 | Anaplastic Oligodendroglioma |
mIDHI | not-deleted | Surgery, IMRT 60Gy, C11-TMZ | Good | |
| 12 | 62/F | 2 | Anaplastic Oligodendroglioma |
mIDHI | deleted | Surgery, VMAT 60Gy | Good | |
| 13 | 28/M | 4 | Astrocytoma | mIDHI | not-deleted | MGMT | Surgery, XRT 60 Gy, C6-TMZ | Good |
| 14 | 37/M | 4 | Astrocytoma | mIDHI | not-deleted | Surgery, IMRT 60 Gy, C4-TMZ, C5-(TMZ+HU), C9-TMZ | Good | |
| 15 | 57/F | 2 | Astrocytoma | wtIDH | not-deleted | XRT 60Gy + C6-TMZ | Good | |
| 16 | 35/M | 3 | Anaplastic Astrocytoma |
wtIDH | not-deleted | Surgery, IMRT 60Gy, C18-TMZ, SRS, C4-Bev | Good | |
| 17 | 35/M | 4 | Glioblastoma | wtIDH | not-deleted | C7/C10, CDK4, EGFR | VMAT 60Gy, C6-TMZ, C2-BEV | Good |
| 18 | 33/F | ND | Not diagnosed | Not diagnosed | Not diagnosed | Not diagnosed | No treatment | Good |
| 19 | 32/F | ND | Not diagnosed | Not diagnosed | Not diagnosed | Not diagnosed | No treatment | Good |
| 20 | 58/M | ND | Not diagnosed | Not diagnosed | Not diagnosed | Not diagnosed | No treatment | Good |