TABLE I:
Metabolite concentrations (I.U.) and quantification error (Cramér-Rao lower bound, CRLB %) in each brain lobe and tissue type. The two bottom rows present the SNR and FWHM values. The last column shows the percentage of voxels inside the brain and FoV that meet the criteria of good quality: CRLB < 20%, FWHM SNR > 5. The values are calculated as the average (standard deviation) across the healthy volunteers imaged by 3D ECCENTRCIC at 3.4 mm isotropic with (9min:20s acquisition time).
| Mean across volunteers (Standard deviation) | Frontal | Limbic | Parietal | Occipital | Temporal | usable voxels mean % (std) | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| WM | GM | WM | GM | WM | GM | WM | GM | WM | GM | ||
| tCre [I.U.] | 3.34 (0.34) | 3.84 (0.04) | 3.22 (0.35) | 4.46 (0.28) | 3.30 (0.28) | 3.95 (0.28) | 3.31 (0.30) | 3.39 (0.19) | 3.09 (0.25) | 3.81 (0.19) | |
| tCre CRLB [%] | 3.25 (0.24) | 3.54 (0.41) | 3.38 (0.31) | 3.18 (0.30) | 3.21 (0.33) | 3.26 (0.26) | 3.45 (0.62) | 3.64 (0.62) | 3.42 (0.37) | 3.33 (0.26) | 73.3 (3.3) |
| NAA [I.U.] | 4.16 (0.98) | 4.51 (0.66) | 4.07 (1.01) | 5.38 (0.90) | 4.31 (0.96) | 4.84 (0.88) | 4.33 (0.98) | 4.18 (0.85) | 3.91 (0.84) | 4.35 (0.73) | |
| NAA CRLB [%] | 3.13 (0.34) | 3.55 (0.64) | 3.26 (0.33) | 3.07 (0.36) | 2.86 (0.26) | 3.05 (0.37) | 3.30 (0.54) | 3.63 (0.64) | 3.32 (0.39) | 3.32 (0.34) | 73.0 (3.5) |
| Ins [I.U.] | 3.49 (0.52) | 3.51 (0.35) | 3.65 (0.60) | 4.28 (0.48) | 3.73 (0.66) | 3.58 (0.29) | 3.74 (0.65) | 3.27 (0.57) | 3.56 (0.65) | 3.39 (0.51) | |
| Ins CRLB [%] | 5.33 (0.64) | 6.04 (0.94) | 5.29 (0.52) | 5.36 (0.42) | 5.16 (0.42) | 5.63 (0.52) | 5.38 (0.48) | 5.84 (0.50) | 5.34 (0.33) | 5.68 (0.40) | 73.0 (3.5) |
| GPC+PCh [I.U.] | 1.03 (0.10) | 0.93 (0.05) | 1.10 (0.10) | 1.24 (0.08) | 1.06 (0.11) | 0.95 (0.09) | 0.94 (0.12) | 0.79 (0.06) | 0.99 (0.07) | 0.98 (0.12) | |
| GPC+PCh CRLB [%] | 3.63 (0.34) | 4.24 (0.59) | 3.46 (0.31) | 3.56 (0.27) | 3.56 (0.29) | 3.97 (0.33) | 4.13 (0.57) | 4.59 (0.64) | 3.68 (0.29) | 3.94 (0.25) | 73.5 (3.3) |
| Glu [I.U.] | 3.86 (0.53) | 4.50 (0.29) | 3.72 (0.49) | 5.24 (0.46) | 3.86 (0.39) | 4.61 (0.39) | 3.80 (0.36) | 3.82 (0.38) | 3.50 (0.35) | 4.29 (0.44) | |
| Glu CRLB [%] | 4.51 (0.51) | 5.01 (0.85) | 4.72 (0.59) | 4.37 (0.47) | 4.31 (0.53) | 4.48 (0.55) | 4.82 (1.14) | 5.22 (1.32) | 4.80 (0.74) | 4.71 (0.64) | 72.8 (3.8) |
| Gln [I.U.] | 0.89 (0.06) | 1.24 (0.25) | 0.83 (0.06) | 1.33 (0.16) | 0.80 (0.16) | 1.08 (0.26) | 0.87 (0.22) | 0.91 (0.21) | 0.80 (0.09) | 1.07 (0.22) | |
| Gln CRLB [%] | 15.93 (2.45) | 14.81 (2.22) | 17.72 (2.68) | 14.38 (2.48) | 17.92 (4.78) | 16.22 (3.24) | 18.99 (5.14) | 18.77 (4.11) | 18.30 (2.95) | 16.45 (2.60) | 56.3 (4.6) |
| GABA [I.U.] | 1.34 (0.09) | 1.48 (0.29) | 1.34 (0.10) | 1.79 (0.37) | 1.37 (0.14) | 1.58 (0.30) | 1.33 (0.18) | 1.37 (0.18) | 1.21 (0.16) | 1.39 (0.32) | |
| GABA CRLB [%] | 8.68 (1.10) | 9.61 (1.51) | 8.86 (1.50) | 8.52 (1.74) | 8.54 (2.08) | 8.78 (1.76) | 9.48 (2.34) | 9.90 (2.22) | 9.60 (2.16) | 9.52 (2.09) | 68.3 (1.5) |
| GSH [I.U.] | 1.07 (0.24) | 1.22 (0.05) | 1.11 (0.26) | 1.45 (0.20) | 1.10 (0.20) | 1.17 (0.07) | 1.05 (0.18) | 1.00 (0.09) | 1.02 (0.17) | 1.14 (0.12) | |
| GSH CRLB [%] | 8.20 (0.88) | 8.77 (1.15) | 8.29 (0.93) | 7.96 (0.79) | 8.04 (1.00) | 8.43 (0.87) | 9.12 (2.01) | 9.80 (1.90) | 8.65 (1.23) | 8.81 (1.17) | 71.5 (3.1) |
| NAAG [I.U.] | 0.82 (0.14) | 0.39 (0.12) | 0.90 (0.13) | 0.49 (0.17) | 0.96 (0.17) | 0.34 (0.13) | 0.78 (0.16) | 0.41 (0.12) | 0.76 (0.11) | 0.35 (0.10) | |
| NAAG CRLB [%] | 14.11 (4.10) | 19.02 (5.07) | 12.43 (3.87) | 17.35 (6.07) | 12.01 (3.14) | 18.03 (5.15) | 15.51 (5.08) | 19.40 (6.62) | 15.36 (5.01) | 20.13 (6.40) | 45.3 (11.6) |
| SNR | 24.64 (4.41) | 23.67 (3.84) | 22.92 (4.50) | 24.53 (4.02) | 25.64 (4.82) | 24.73 (4.17) | 22.48 (6.13) | 21.32 (5.56) | 22.07 (4.23) | 22.40 (3.37) | Ø |
| FWHM [Hz] | 11.43 (0.91) | 12.09 (0.77) | 11.28 (1.15) | 11.13 (1.13) | 10.21 (0.79) | 11.02 (0.84) | 11.64 (0.91) | 12.33 (1.04) | 12.26 (1.23) | 12.38 (1.22) | Ø |