Table 5.
Cross-significance of top SNPs for Retinal Pathology Characterized by Pre-retinal Neovascular Disease including ROP and Diabetic Retinopathy (GOLDR)
| GOLDR | ROP | ||||||
|---|---|---|---|---|---|---|---|
| odds ratio | P value | odds ratio | P value | ||||
| GLI3 | rs74527981 | 7 | 42205730 | 2.22 | 9.3E-04 | na | Na |
| rs17172024 | 7 | 42210112 | 2.22 | 9.3E-04 | na | Na | |
| rs2058019 | 7 | 42187113 | ns | Ns | 1.27 | 4.90E-09 | |
| CLDN12 | No loci associated with DR for whole region | ||||||
| DEF8, TUBB3 | No loci associated with DR for whole region | ||||||
| DCLK1 | rs35596426 | 13 | 36452952 | 5.18 | 4.3E-04 | Na | Na |
| rs9576059 | 13 | 36452266 | 4.83 | 5.9E-04 | Na | Na | |
| rs61948265 | 13 | 35984893 | ns | Ns | 1.14 | 6.50E-07 | |
| SP4 | rs11770747 | 7 | 21552122 | 1.96 | 7.6E-04 | ns | Ns |
| rs78539005 | 7 | 21547126 | 2.51 | 8.5E-04 | 1.09 | 0.03 | |
| rs141411503 | 7 | 21425951 | ns | Ns | 1.21 | 8.38E-07 | |
| ARHGEF7 | No loci associated with DR for whole region | ||||||
| PTPRD | rs79715438 | 9 | 8809579 | 3.48 | 5.0E-04 | na | Na |
| rs75240118 | 9 | 8809921 | 3.48 | 5.0E-04 | na | Na | |
| rs80041124 | 9 | 8810631 | 3.48 | 5.0E-04 | na | Na | |
| rs76777639 | 9 | 8488087 | 3.30 | 9.6E-04 | na | Na | |
| rs529032346 | 9 | 8499029 | 3.30 | 9.6E-04 | na | Na | |
| rs9644892 | 9 | 8800078 | ns | Ns | 1.1 | 2.14E-06 | |
| DPP4 | No loci associated with DR for whole region | ||||||
| RPL30, RIDA | rs2514337 | 8 | 98113613 | 0.49 | 5.4E-04 | 0.94 | 4.4E-04 |
| rs2447504 | 8 | 98113678 | 0.49 | 5.4E-04 | 0.94 | 4.4E-04 | |
| rs2306129 | 8 | 98093498 | 0.66 | 0.04 | 1.09 | 3.77E-06 | |
| PRPF4B | No loci associated with DR for whole region | ||||||
ns: not significant.
na: association tests not applicable for SNPs with MAF less than 0.05.