Table 9:
Top gene RNA-sequencing-based expression in human donor macular retinal or RPE tissue isolated using the Utah Protocol:
| hg19 Position | Gene Name | Tissue Type with Higher Expression | Fold Change between RPE and Retina | P-value |
|---|---|---|---|---|
| chr16:89985572–90002500 | TIJBB3 | Neurosensory Retma | 35.201 | 1.03E-130 |
| chr8:99037078–99058697 | RPL30 | RPE | 2.974 | 5.69259E-61 |
| chr13:36345477–36705443 | DCLK1 | Neurosensory Retina | 10.303 | 6.27566E-29 |
| chr7:1031 12230–103629963 | RELN | Neurosensory Retina | 10.599 | 2,41595E-28 |
| chr7:21467651–21554440 | SP4 | Neurosensory Retina | 2.467 | 2,09322E-23 |
| chr16:90014332–9003446S | DEFS | Neurosensory Retina | 1.709 | 1.10S65E-20 |
| chr7:90013034–90142716 | CLDN12 | Neurosensory Retina | 2.050 | 7.47808E-16 |
| chr7:42000547–42277469 | GL13 | RPE | 2.454 | 3.30197E-15 |
| chr9:B314245–10612723 | PTPRD | Neurosensory Retina | 3.962 | 5.21447E-13 |
| chr2:162848750–162931052 | DPP4 | RPE | 2.725 | 2.96267E-OS |
| chr13:111766158–111768025 | ARIIGEF7 | Neurosensory Retina | 2.276 | 3,91738E-05 |
Differential expression between macular retinal and RPE/Choroid was calculated and p-values corrected for multiple testing using Benjamini-Hockberg. The absolute fold change is represented between the tissue with higher expression versus the tissue with lower expression.