Figure 2.

Distribution of damage severity following SAH. A: At 30 days following SAH, damage was observed to occur in multiple areas including the cortices, hippocampus, thalamus, hypothalamus, striatum and amygdala, with both severe damage (red) defined as more than 70% unhealthy cells and moderate damage (blue) defined as 20–70% healthy cells present in most regions assessed. Black bar = 5mm. B: The relative distribution of severe and moderate potential damage in different brain regions was quantified. Most regions displayed 10–30% area of potentially unhealthy regions, with a mixture of severe and moderate potential damage generally favoring moderate damage in all regions except the thalamus and striatum. C: The density of healthy cells corresponded to regions of potential damage observed previously. The cortex, hypothalamus, and amygdala exhibited both moderate and severely decreased healthy cell density. Hippocampal regions CA1, CA3 and DG contained both moderate and severe reductions in healthy cell density, while the DH region was entirely severely damaged. The striatum and thalamus also showed severe reductions in healthy cell density.