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[Preprint]. 2023 May 19:rs.3.rs-2943917. [Version 1] doi: 10.21203/rs.3.rs-2943917/v1

Figure 8.

Figure 8

SAH induces situational depression measured via Porsolt Forced Swim (PFS) in association with cortical, subcortical and white matter injury. A: SAH group animals showed a significant decrease in highly mobile behavior, indicating a more depressed state. B: Following SAH, animals displayed a significant increase in immobile behavior consistent with depression. C: Severe damage (red outline) was observed following SAH in the thalamus, along with moderate damage (blue outline) in the hypothalamus and ventromedial prefrontal cortex (VMPC). Loss of confluence was observed in the corpus callosum (yellow outline). Black bar = 100μm; white bar = 25μm; red arrowheads = unhealthy cells; blue arrows = examples of healthy cells; solid outline = 20x = 0.2mm2; dashed outline = 40x = 0.01mm2; ** P < 0.01, **** P < 0.0001, mixed-effects ANOVA.