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[Preprint]. 2023 May 25:rs.3.rs-2960373. [Version 1] doi: 10.21203/rs.3.rs-2960373/v1

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Anti-CSP Antibody Response by Transmission Intensity, All Study Areas and Study Area Adjusted (A: Pre-Vaccination, B: One Month Post-Vaccination)

(A) Children have a very low anti-circumsporozoite protein (CSP) antibody response on the day of the first vaccine dose.

(B) One month after vaccination, children in higher transmission areas have higher antibody responses to RTS,S/AS01 vaccination. This positive relationship disappears when adjusting for study area. Antibody responses were elevated in Ghana, the highest transmission study area.