Table 1.
Expression spectrum of SIGLECs on human or murine cells
| SIGLECs | Other names | Expressing cells | Refs |
|---|---|---|---|
| SIGLEC1 | CD169 | Macrophage, Dendritic cell | 14,18,19 |
| SIGLEC2 | CD22 | B cell, cDC*, Mast cell | 14,18 |
| SIGLEC3 | CD33 | Diverse myeloid-derived cells, NK cell, T cell | 14,18,20 |
| SIGLEC4 | MAG | Oligodendrocyte, Schwann cell | 14,18 |
| SIGLEC5 | CD170 | Diverse myeloid-derived cells, T cell, B cell | 14,17,18,21,22 |
| SIGLEC6 | CD327 | Trophoblast, Mast cell, Basophil, B cell, Myeloid leukemia | 14,17,18,23 |
| SIGLEC7 | CD328 | Diverse myeloid-derived cells, NK cell, T cell | 14,18,24,25 |
| SIGLEC8 | – | Eosinophil, Basophil, Mast cell | 14,18 |
| SIGLEC9 | CD329 | Diverse myeloid-derived cells, T cell, NK cell | 14,18,26 |
| SIGLEC10 | – | Macrophage, NK cell, Eosinophil, B cell, T cell | 14,18,27 |
| SIGLEC11 | – | Microglia, Macrophage, Ovarian stromal cell | 14,18,28 |
| SIGLEC12 | Pseudogene | Macrophage, Unknown | 14,18,29 |
| SIGLEC14 | – | Diverse myeloid-derived cells | 14,18,30 |
| SIGLEC15 | CD33L3 | Macrophage, Osteoclast | 14,18,31 |
| SIGLEC16 | – | Macrophage, Microglia | 14,18,21 |
| mSiglec1# | mCD169 | Macrophage, Dendritic cell | 14,18,19,32 |
| mSiglec2 | mCD22 | B cell, cDC*, Mast cell | 14,18,33 |
| mSiglec4 | mMAG | Oligodendrocyte, Schwann cell | 14,18,34 |
| mSiglec15 | mCD33L3 | Macrophage, Osteoclast | 14,18,31 |
| mSiglec3 | mCD33 | Neutrophil, Macrophage, Microglia | 35,36 |
| mSiglecE | Homolog of SIGLEC9 | Diverse myeloid-derived cells, NK cell, Dendritic cell | 37–42 |
| mSiglecF | Homolog of SIGLEC8 | Immature cells of myeloid lineage, Eosinophil, Neutrophil | 35,43–49 |
| mSiglecG | Homolog of SIGLEC10 | Eosinophil | 34,43,44 |
| mSiglecH | Possible human homolog of SIGLEC14 and SIGLEC16? | Plasmacytoid dendritic cell (pDC), Macrophage | 43,50–52 |
#The “m” prefix indicates murine origin. *myeloid-derived DC.