(A) Baseline [Ca2+] levels, (B) peak [Ca2+] levels, (C) Ca2+ transient amplitude in male cardiomyocytes exposed to CdCl2 for eight weeks (n = 68–80 cardiomyocytes from 5 hearts/group). (A) Baseline [Ca2+] levels, (B) peak [Ca2+] levels, (C) Ca2+ transient amplitude in female cardiomyocytes exposed to CdCl2 for eight weeks (n = 69–92 cardiomyocytes from 5 hearts/group). Datasets were analyzed via Mann–Whitney test (****p < 0.05 vs. non-exposed control male, *p < 0.05 vs. non-exposed control female).