Table 1.
Echocardiographic parameters for male and female hearts at zero-, four-, and eight-weeks of CdCl2 exposure.
| Male Control | Male Cd | Female Control | Female Cd | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Week 0 | Week 4 | Week 8 | Week 0 | Week 4 | Week 8 | p-value | Week 0 | Week 4 | Week 8 | Week 0 | Week 4 | Week 8 | p-value | |
| IVS;d | 0.915 | 0.854 | 0.971 | 0.925 | 0.894 | 0.888 | 0.063 | 0.919 | 0.905 | 0.873 | 0.890 | 0.909 | 0.877 | 0.779 |
| IVS;s | 1.392 | 1.477 | 1.526 | 1.468 | 1.397 | 1.391 | 0.012 | 1.448 | 1.395 | 1.424 | 1.386 | 1.406 | 1.366 | 0.442 |
| LVID;d | 2.741 | 2.897 | 2.964 | 2.699 | 2.917 | 2.988 | 0.761 | 2.606 | 2.748 | 2.808 | 2.736 | 2.732 | 2.855 | 0.030 |
| LVID;s | 1.613 | 1.583 | 1.738 | 1.607 | 1.786 | 1.925 | 0.052 | 1.486 | 1.535 | 1.654 | 1.583 | 1.548 | 1.649 | 0.053 |
| LVPW;d | 0.971 | 0.929 | 0.907 | 0.888 | 0.923 | 0.917 | 0.346 | 0.952 | 1.001 | 0.897 | 1.003 | 0.984 | 0.852 | 0.342 |
| LVPW;s | 1.310 | 1.330 | 1.286 | 1.311 | 1.328 | 1.272 | 0.985 | 1.229 | 1.348 | 1.223 | 1.285 | 1.385 | 1.232 | 0.791 |
| EF | 73.747 | 78.138 | 73.821 | 73.073 | 70.927 | 66.713 | 0.006 | 76.018 | 77.056 | 73.668 | 74.975 | 76.263 | 74.959 | 0.141 |
| FS | 41.066 | 45.319 | 41.367 | 40.411 | 38.900 | 35.901 | 0.004 | 42.941 | 44.128 | 41.071 | 42.162 | 43.372 | 42.240 | 0.162 |
| LV Mass | 67.122 | 65.965 | 73.846 | 61.027 | 69.075 | 70.816 | 0.435 | 61.721 | 67.600 | 62.436 | 66.453 | 66.254 | 62.069 | 0.588 |
| LV Volume;d | 28.190 | 32.155 | 34.091 | 27.156 | 32.891 | 34.981 | 0.740 | 24.834 | 28.216 | 29.810 | 27.949 | 27.837 | 31.063 | 0.041 |
| LV Volume;s | 7.347 | 7.006 | 8.930 | 7.289 | 9.679 | 12.069 | 0.059 | 5.931 | 6.463 | 7.825 | 6.990 | 6.643 | 7.762 | 0.079 |
| SV | 20.844 | 25.150 | 25.162 | 19.866 | 23.211 | 22.913 | 0.755 | 18.901 | 21.754 | 21.983 | 20.959 | 21.195 | 23.301 | 0.046 |
| CO | 14.153 | 16.869 | 17.780 | 12.926 | 15.480 | 16.155 | 0.950 | 13.135 | 15.128 | 15.427 | 13.019 | 14.568 | 16.057 | 0.436 |
| HR | 680.795 | 670.902 | 705.792 | 656.252 | 669.094 | 704.237 | 0.485 | 695.345 | 695.519 | 703.529 | 619.045 | 687.974 | 688.88 | 0.058 |
Interventricular septum thickness at end diastole (IVS;d) and end systole (IVS;d), left ventricular internal dimension at end diastole (LVID;d) and end systole (LVID;s), left ventricular posterior wall thickness at end diastole (LVPW;d) and end systole (LVPW;s), ejection fraction (EF), fractional shortening (FS), left ventricular mass (LV Mass), left ventricular volume at end diastole (LV Volume;d) and end systole (LV Volume;s), stroke volume (SV), cardiac output (CO), and heart rate (HR). Datasets were analyzed via two-way ANOVA with Dunnett’s multiple comparisons test (n = 10 mice/group).