Skip to main content
. 2023 May 8;14(22):5936–5944. doi: 10.1039/d3sc00678f

Copper-binding affinitya for Aβ42 stereoisomers.

Aβ42 K D1 [μM] (+1 Cu2+) K D2 [μM] (+2 Cu2+) Fold change
K D1 K D2
WT 0.04 ± 0.01 27.04 ± 1.88 1.00 1.00
dD 1.50 ± 0.02 33.31 ± 3.26 34.12 1.23
dS 0.70 ± 0.14 46.35 ± 3.85 15.84 1.71
dDdS 0.31 ± 0.06 19.77 ± 2.63 7.15 0.73
a

All data in this table represents triplicate measurements with SD values for error ranges. The calculation of KD fold changes is based on the normalization of WT group to be 1.0.