Table 2. Plasma glucose levels.

Pre-breakfast/pre-main evening meal plasma glucose levela (mmol/L)	Adjustment of dose according to units of insulin (U)
<3.1b	-4 (If dose is >45 U, reduce by 10%)
3.1—3.8b	-2 (If dose is >45 U, reduce by 5%)
3.9-4.9	0
5.0-6.9	+2
7.0-7.9	+4
8.0-8.9	+6
≥9.0	+8

^aMean of three consecutive measurements for up titration; the pre-breakfast plasma glucose level is used for once-daily dosing and the pre-breakfast and pre-evening meal plasma glucose levels for twice-daily dosing.

^bDose reduction is based on one measurement unless there is an apparent explanation for the low value, such as a missed meal.