TABLE 1.
Characteristics of whole blood donors.
| Parameter | Controls (n = 7) | JAK2V617F+ (n = 9) | 95% CI of the differenceb | p value | ||
|---|---|---|---|---|---|---|
| Age | 32 (range 18–62) | 58 (range 25–79) | NA | NA | ||
| Sex | ||||||
| Male | 5 | 3 | NA | NA | ||
| Female | 2 | 6 | ||||
| Ethnicity | ||||||
| White | 3 | 7 | NA | NA | ||
| Non-White | 4 | 2 | ||||
| Complete blood count parametersa | ||||||
| White blood cells (107/dL) | 7.3 ± 0.8 | 8.3 ± 1.1 | −2.0 | 4.11 | .5 | |
| Hemoglobin (g/dL) | 13.6 ± 0.3 | 13.3 ± 0.5 | −1.7 | 1.2 | .7 | |
| Hematocrit (%) | 37.4 ± 1.1 | 42.8 ± 1.8 | 0.5 | 10.2 | .03 | |
| Platelet (10 7 /dL) c | 238 ± 38 | 602 ± 168 | 8.8 | 786 | .05 | |
| Thrombosis history (n, %) | NA | 2 (33.3%) | NA | |||
| Phenotyped | NA | NA | ||||
| Essential thrombocythemia | 1 | |||||
| Polycythemia vera | 7 | |||||
| Myelofibrosis | 1 | |||||
| Medications | NA | NA | ||||
| Aspirin | 6 | |||||
| Hydroxyurea | 4 | |||||
| Interferon | 0 | |||||
| Ruxolitinib | 0 | |||||
a
values mean ± SM of means.
b
CIs and p value from unpaired t-test.
c
t-test with Welch’s correction for unequal SDs used.
d
Phenotype based on electronic medical record, laboratory values, and bone marrow at the time of diagnosis. Bold values indicate values with significant trends or differences.