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. 2023 Jun 7;18(6):e0286724. doi: 10.1371/journal.pone.0286724

Fig 3. CCX559 enhances the function of primary human T cells in vitro.

Fig 3

(A) CCX559 increased human T cell IFNγ secretion in a mixed lymphocyte reaction. Total CD4+ T cells and monocyte-derived dendritic cells from separate healthy donors were combined in a 1:10 cell ratio, and IFNγ was measured in the culture supernatant after 5 days. The graph shows a representative allogeneic donor pair out of 3 total. (B) A375-eGFP cells and SEB-stimulated human PBMCs were incubated together with CCX559 (green circles), which dose-dependently reduced the number of live cells as measured by eGFP (RLU). The inactive compound (black circles) had no effect on cell killing. (C) In the absence of PBMCs, the same CCX559 doses had no effect on cell survival.