Table 2. Univariate and multivariate Cox regression model for potential predictors of overall survival in colorectal cancer patients.

DM: diabetes mellitus; HTN: hypertension; HLD: hyperlipidemia; CKD: chronic kidney disease; PPI: proton pump inhibitor

	Univariate		Multivariate
	HR (95% CI)	p-value	HR (95% CI)	p-value
Sex (1=men, 2=women)	0.889 (0.7142 to 1.107)	0.293
Age (continuous)	1.035 (1.026 to 1.044)	< 0.001	1.039 (1.029 to 1.048)	< 0.001
Race (reference = white)
Asian	0.947 (0.728 to 1.232)	0.684
Native Hawaiian or Other Pacific Islander	0.937 (0.661 to 1.330)	0.716
Grade (reference = G1-2)
G3-4	1.765 (1.349 to 2.308)	< 0.001	1.471 (1.122 to 1.928)	0.008
Stage	1.713 (1.509 to 1.943)	< 0.001	2.134 (1.806 to 2.520)	< 0.001
Chemotherapy (reference = no)	0.995 (0.800 to 1.238)	0.965
PPI	1.111 (0.869 to 1.420)	0.402	1.095 (0.846 to 1.418)	0.482
HTN	1.133 (0.902 to 1.424)	0.284
HLD	0.913 (0.734 to 1.137)	0.416
DM	1.028 (0.806 to 1.311)	0.822
CKD	1.456 (1.098 to 1.931)	0.009	1.167 (0.867 to 1.572)	0.273