Skip to main content
. Author manuscript; available in PMC: 2024 Jun 1.
Published in final edited form as: Mol Cell Neurosci. 2023 Feb 28;125:103826. doi: 10.1016/j.mcn.2023.103826

Figure 4. Dsup alters the structure of chromatin in primary neurons.

Figure 4.

(a) Representative electron micrograph of cultured cortical neurons infected with the BFP lentivirus (BFP) or the Dsup-BFP lentivirus. Primary cultures were infected, fixed 72 hours when the expression plateaued and >70% of cells were expressing the constructs, and processed for electron microscopy imaging. Results were pooled from two experiments. Bar (BFP), 2 μm; bar (Dsup-BFP), 1 μm. (b) The percentage of condensed chromatin was calculated in the BFP-infected and Dsup-BFP-infected cohorts. P=0.0002 (t-test). (c) The cytoplasm of the neuron from the Dsup-BFP-infected cohort from (a) does not exhibit major abnormalities. Bar, 1 μm.