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. Author manuscript; available in PMC: 2024 Jun 1.
Published in final edited form as: Mol Cell Neurosci. 2023 Feb 24;125:103824. doi: 10.1016/j.mcn.2023.103824

Figure 2. Blocking H3Q5dop in NAc, but not mPFC, inhibits cocaine-seeking.

Figure 2.

(A) Timeline of cocaine SA (extended access) drug-seeking experiments following viral transduction with either lenti-H3.3WT or lenti-H3.3Q5A viruses. Cocaine SA rats were infected intra- (B) NAc (n = 7/group) or (C) mPFC (n = 7/group) on AD1 with either lenti-H3.3WT or lenti-H3.3Q5A viruses, and following 30 days of abstinence were subjected to 1 hr of cocaine-seeking on AD30. Unpaired Student’s t-tests, **p<0.01. Data presented as average ± SEM.