Table 2.

Potential risk factors for late-onset neutropenia after rituximab supported by multiple studies

Risk Factor	References
Advanced stage of cancer	Choi et al. 2014; Nitta et al. 2007; Arai et al. 2015
Exposure to chemotherapeutics (e.g., purine analogs)	Wolach et al. 2010; Nitta et al. 2007; Hirayama et al. 2009; Lemieux et al. 2004; Cattaneo et al. 2006; Cairoli et al. 2004
IgG FcγIIIa receptor polymorphism (158V/V or 158V/F)	Weng et al. 2010; Tesfa and Palmblad 2011; Wolach et al. 2012; Li et al. 2010; Keane et al. 2012
Autologous peripheral blood stem cell transplantation	Lemieux et al. 2004; Hirayama et al. 2009; Cairoli et al. 2004; Flinn et al. 2000
Immunosuppressants (e.g., methotrexate)	Nitta et al. 2007; Arai et al. 2015; Castillo et al. 2019
Older age	Moore 2016; Freifeld et al. 2011; Salmon et al. 2015; Choi et al. 2014; Arai et al. 2015