TABLE 3.

Adjusted Risk for All Delirium Cases by Baseline 24-Hour Rest–Activity Rhythm Quartiles

	24-Hour Rest–Activity Rhythm Measures
Models	Amplitude, Q1 vs Q4	Acrophase, Q4 vs Q1	Interdaily Stability, Q1 vs Q4	Intradaily Variability, Q4 vs. Q1
Model A	1.94 (1.53–2.46)***	1.18 (0.95–1.47)	1.30 (1.03–1.63)*	1.49 (1.18–1.88)***
Model B	1.70 (1.34–2.15)***	1.05 (0.82–1.31)	1.25 (0.99–1.58)	1.49 (1.17–1.87)**
Model C	1.49 (1.18–1.89)**	1.17 (0.95–1.48)	1.15 (0.91–1.46)	1.20 (0.94–1.53)
Model D	1.65 (1.30–2.09)***	1.18 (0.94–1.47)	1.26 (0.99–1.59)	1.49 (1.17–1.88)***
Model E	1.73 (1.36–2.17)***	1.16 (0.93–1.45)	1.21 (0.96–1.52)	1.44 (1.14–1.82)**

Note: Data are hazard ratio (95% confidence interval) from the following Cox regression models.

Model A: adjusted for age, sex, education, Townsend deprivation index, ethnic background, and number of hospitalizations.

Model B: adjusted for Model A plus total nighttime sleep duration, number of awakenings.

Model C: adjusted for Model A plus mean activity.

Model D: adjusted for Model A plus mean reaction time.

Model E: adjusted for Model A plus body mass index, cardiovascular disease, morbidity burden.

^*p < 0.05.

^**p < 0.01.

^***p < 0.001.

Abbreviation: Q1 = quartile 1 (lowest); Q4 = quartile 4 (highest).