Table 1:
Effects of the WHIM CXCR41013 (p.S338X) mutation on the absolute T cell numbers in naïve +/+ mice compared to +/w littermates (× 106 cells ± SEM) and on the abundance of +/w cells relative to +/+ cells in reconstituted +/+ and +/w hosts. Significant differences between +/+ (not underlined) and +/w (underlined) are marked in bold.
| Cell populations | Naïve mice (# × 106 in +/+ mice vs. +/w mice) |
Transplanted mice | ||
|---|---|---|---|---|
| +/+ hosts (% donor cells) |
+/w hosts (% donor cells) |
|||
| Blood | CD4+ T cells | 1.92±0.2vs.1.13±0.1 | 20.54±1.2vs.28.64±3.0 | 18.04±1.9vs.22.88±3.3 |
| CD8+ T cells | 1.1±0.1vs.0.41 | 8.78±0.6vs.6.8±0.6 | 7.14±0.7vs.5.38±0.7 | |
| CD4/CD8 | 1.74±0.1vs.2.97±0.2 | 2.45±0.2vs.4.23±0.3 | 2.56±0.1vs.4.38±0.4 | |
| Thymus | CD4 SP | 8.39±0.9vs.11.01±0.6 | 8.37±0.3vs.9.3±0.5 | 8.16±0.3vs.9.51±0.6 |
| CD8 SP | 3.33±0.2vs.4.5±0.3 | 1.33±0.7vs.1.87±0.1 | 1.26±0.1vs.2.08±0.2 | |
| CD4/CD8 SP | 2.73±0.1vs.2.18±0.1 | 6.38±0.4vs.5.13±0.3 | 6.83±0.4vs.4.91±0.3 | |
| CD24hiCD4SP | 7.81±0.8vs.8.82±0.5 | 88.93±0.4vs.87.55±0.7 | 87.15±0.6vs.84±0.8 | |
| CD24loCD4SP | 0.96±0.2vs.1.27±0.1 | 9.37±0.5vs.10.9±0.6 | 11.01±0.7vs.14.13±0.9 | |
| CD24hiCD8SP | 1.65±0.1vs.1.36±0.2 | 48.21±1.4vs.39.75±1.9 | 46.5±1.5vs.36.75±1.2 | |
| CD24loCD8SP | 1.59±0.1vs.2.36±0.2 | 25.86±1.2vs.37.77±1.4 | 28.06±0.8vs.44.25±0.9 | |
| Spleen | CD4+ T cells | 17.55±1.4vs.8.21±0.4 | 28.23±0.9vs.27.07±1.5 | 28.1±0.8vs.24.36±1.4 |
| CD8+ T cells | 10.09±1.2vs.3.01±0.2 | 9.22±0.3vs.9.16±0.5 | 8.62±0.2vs.6.82±0.3 | |
| CD4/CD8 | 1.79±0.1vs.2.78±0.1 | 3.09±0.1vs.3.03±0.2 | 3.28±0.1vs.3.57±0.1 | |
| BM | CD4+ T cells | 0.11vs.0.233 | 1.79±0.1vs.1.95±0.2 | 2.42±0.1vs.2.01±0.2 |
| CD8+ T cells | 0.2vs.0.42 | 1.52±0.1vs.3.93±0.3 | 2.69±0.2vs.3.38±0.4 | |
| CD4/CD8 | 0.62vs.0.55 | 1.21vs.0.46 | 0.95±0.1vs.0.63 | |
| mLN | CD4+ T cells | 5.41±0.8vs.5.40±0.5 | 42.10±1.0vs.31.16±1.5 | 43.82±0.9vs.35.23±1.2 |
| CD8+ T cells | 3.12±0.5vs.2.19±0.3 | 18.51±0.5vs.11.4±0.8 | 16.66±0.3vs.10.55±0.4 | |
| CD4/CD8 | 1.69vs.2.53±0.1 | 2.29±0.1vs.2.84±0.2 | 2.64±0.1vs.3.38±0.1 | |
| iLN | CD4+ T cells | 1.59vs.1.29±0.1 | 45.48±1.8vs.50.09±2.4 | 44.94±1.5vs.50.32±2.0 |
| CD8+ T cells | 0.93±0.1vs.0.44 | 20.18±0.9vs.15.61±0.9 | 20.74±0.7vs.14.74±0.6 | |
| CD4/CD8 | 1.69±0.1vs.2.98±0.1 | 2.3±0.1vs.3.35±0.2 | 2.18±0.1vs.3.47±0.2 | |