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. Author manuscript; available in PMC: 2024 Jun 1.
Published in final edited form as: Structure. 2023 Apr 28;31(6):713–723.e3. doi: 10.1016/j.str.2023.04.005

Figure 5: Performance of computational protocols on GFP and Ricin dataset.

Figure 5:

A. Tolerated deletion mutations in blue and non-tolerated in orange mapped on GFP structure17; B. Deletion mutants with remaining Ricin activity in orange and deletion mutations without activity in blue21,23; C. Distribution of ΔΔG values from AlphaFold2-RosettaRelax protocol from tolerated and non-tolerated deletion mutants in GFP; stars indicate p-values calculated from Mann-Whitney test with a p-value of 2.12×103 and D. for Ricin with a p-value of 1.8×103. E. Distribution of WCN for tolerated and non-tolerated deletion mutations in GFP with a p-value of 6.84×105 and F. in Ricin with a p-value of 0.26. G. ΔΔG values plotted against average pLDDT values from AlphaFold2 for GFP and H. for Ricin. Black lines represent values obtained for GFP and Ricin wildtype respectively. Error bars depict standard error.