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The effects of caffeine (3 mg/kg, i.p., A and B), DPCPX (2 mg/kg, i.p., C and D), or ZM241385 (1 mg/kg, i.p., E and F) in the antidepressant-like effect of guanosine in mice subjected to the tail suspension test and open-field test. Values are expressed as means ± S.E.M. (n = 8) followed by two-way ANOVA. *P < 0.05 and **P < 0.01 as compared with the vehicle-treated group (i.e., significant main effect of guanosine)
