Table 4.

Summary of BREM by age subgroup.

Age range*	Parameter	Pooled estimate (95% CI)	Between study standard deviations* (95% CI)	${\widehat{\rho }}_{\tau }$ (95% CI)	Area of prediction region
$\left[0,,,35\right]$	FPR	0.18 (0.15, 0.22)	0.66 (0.42, 0.86)	0.40 (− 0.08, 0.84)	18.31
	TPR	0.88 (0.80, 0.94)	1.41 (0.82, 2.02)
$\left(35,,,51\right]$	FPR	0.18 (0.15, 0.22)	0.68 (0.47, 0.86)	0.56 (0.15, 1.00)	11.43
	TPR	0.82 (0.76, 0.87)	0.93 (0.51, 1.30)
$\left(51,,,64\right]$	FPR	0.15 (0.12, 0.18)	0.63 (0.41, 0.80)	0.66 (0.20, 1.00)	8.24
	TPR	0.79 (0.73, 0.85)	0.80 (0.41, 1.14)
$(64,\infty )$	FPR	0.14 (0.11, 0.17)	0.75 (0.49, 0.95)	0.42 (− 0.13, 1.00)	15.18
	TPR	0.85 (0.78, 0.92)	0.98 (0.42, 1.49)

*The 25th, 50th and 75th percentiles were used to define the age ranges.