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. 2023 Jun 7;14:3280. doi: 10.1038/s41467-023-38383-y

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© The Author(s) 2023, corrected publication 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — Plasma samples were generated as part of: (a) the Swedish VEBIOS ER or (b) the Swedish DFW-VTE study, both of which recruited patients presenting with suspected VTE. Samples were drawn pre- treatment, and cases and controls were identified based on confirmed or ruled out diagnosis. c The French FARIVE study recruited patients with confirmed acute VTE, with controls recruited from hospital patients treated for non-VTE causes. Samples were drawn within 1 week from diagnosis, during initiation of treatment (d) The Swedish VEBIOS Coagulation or (e), Spanish RETROVE study recruited cases from patients who had a prior first time VTE, sampled post-treatment (6–12 months anticoagulants), with healthy controls recruited from the general population. CFHR5 concentration was measured in the respective samples using a dual binder assay. Case and control groups was compared using a linear model adjusting for age and sex (3a–e). ***p < 0.001, ****p < 0.0001. OR (1 SD) = Odds ratio for 1 standard deviation elevation. CI confidence interval. All dot plots are represented as median value with 95% CI. Source data are provided as a Source Data file.