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. 2023 Jun 7;14:3280. doi: 10.1038/s41467-023-38383-y

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© The Author(s) 2023, corrected publication 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a Manhattan plot of the meta-analysis on INVENT-MVP consortium resources [17] showing six loci associated with CHFR5 plasma levels and VTE risk: CFHR1, CFHR4 (rs10737681, p = 2.94E-396), HNF1A (rs2393776, p = 1.48E-21), JMJD1C (rs7916868, p = 4.61E-12), TRIB1 (rs28601761, p = 4.39E-09), DNAH10 (rs7133378, p = 2.43E-08) and HNF4A (rs1800961, p = 4.97E-08). Lead SNPs at HNF1A and DNAH10 are rs2393776 and rs7133378, respectively. They are ~3 Mb apart and do not show any linkage disequilibrium (pairwise r² = 0). b Regional association plot¹²⁷ at the Chromosome 1 locus covering >10 Mb from CFHR1 to CFHR5 around the lead SNP associated with CFHR5 plasma levels. c CFHR5 plasma levels for 16 patients who are carriers of rare non-synonymous CFHR5-associated variants (rs139017763, rs41299613 or rs35662416) and non-carriers (n = 1214). t-test, two sided. *****p < 0.00001. Dot plot (c) is represented as median value with 95% CI. See also Supplementary data 1 [Tabs_11–13]. Source data are provided as a Source Data file (c).