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. 2023 Jun 7;14:3280. doi: 10.1038/s41467-023-38383-y

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© The Author(s) 2023, corrected publication 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — Platelet activation was measured by surface expression of (a) P-selectin, (b) activated GP IIb/IIIa (PAC1⁺) or (c) CD63, following treatment of platelet rich plasma with different concentrations of adenosine diphosphate (ADP), convulxin or TRAP6, [a–c: top, middle and bottom panels, respectively] following pre-incubation with recombinant CFHR5, or PBS control. d Platelet aggregation was measured in response to ADP (2 μm) following pre-incubation with recombinant CFHR5, or PBS control: representative aggregation curve [left], maximum aggregation [middle] and slope [right], of four independent experiments. ADP-induced platelet activated GP IIb/IIIa (PAC1⁺) was measured following preincubation with: (e) DMSO (control) or compstatin, or (f) PBS (control) or an anti-C3a antibody, followed by treatment with PBS or rCFHR5. US: unstimulated (PBS control). Each experiment is represented by an individual point and paired experiments connected by a dotted line. Anova (a–c) and t-test (d–f) were performed (two-tailed). *p < 0.05 **p < 0.01 ***p < 0.001 (p for trend bottom right). Source data are provided as a Source Data file (Fig. 5).