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. 2023 Jun 7;13:9226. doi: 10.1038/s41598-023-36202-4

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Quantification of permeability in the streptozotocin (STZ) diabetic mouse model using fluorophotometry. Mice that had been induced with STZ to be diabetic 10 weeks previously were used in this experiment, and compared with age-matched non-diabetic control animals. (a) Blood glucose levels were significantly elevated in STZ diabetic mice, 10 weeks following diabetes induction, whereas (b) body weight was not significantly different from non-diabetic control mice. Levels of fluorescein in (c) the retina, (d) the vitreous and (e) the anterior chamber were all significantly increased in STZ mice at various time points from 40 to 60 min post-injection of 50 mg/kg subcutaneous fluorescein, compared with non-diabetic controls. Data shown in (c–e) are corrected to plasma levels of fluorescein. (f) Plasma levels of fluorescein were not significantly different between STZ diabetic and non-diabetic control mice treatment groups. N = 6–16 eyes per time point. Blood glucose and body weight assessed statistically by Two-way ANOVA with repeated measures, followed by Tukey’s multiple comparison test. Ocular compartment leakage assessed statistically by Two-way ANOVA with repeated measures, followed by Bonferroni’s multiple comparison test. * P < 0.05, ** P < 0.01, **** P < 0.0001. Data are given as means ± SEM.