| Trial |
No. |
Intervention |
Comparison |
Duration |
Outcomes |
Results (between‐group comparison) |
| Albertazzi 1998 |
104 |
60 g soy powder (76 mg/d isoflavones) |
Placebo |
12 weeks |
Withdrawal due to adverse events |
20% in soy group versus 23% in placebo group (P value not reported) |
| Ferrari 2009 |
180 |
Soy isoflavone extract (80 mg) with high dose of genistein (60 mg) |
Placebo |
12 weeks |
Satisfaction rates |
79.1% in genistein group; 69.1% in placebo group (P value not reported) |
| Heger 2006 |
110 |
Extract of ERr 731, an extract of the roots of Rheum rhaponticum
|
Placebo |
12 weeks |
Satisfaction rates |
63% in ERr 731 group satisfied at end of treatment; 32% in placebo group (P value not reported) |
| Knight 2001 |
24 |
Soy powder 60 g/d for beverage (134.4 mg/d isoflavones) |
Placebo |
12 weeks |
Withdrawal due to adverse events |
25% in soy group versus 8% in placebo group (P value not reported) |
| Kotsopoulos 2000 |
94 |
Soy powder for beverage (118 mg/d isoflavones) |
Placebo |
12 weeks |
Withdrawal due to adverse events or inability to tolerate treatment |
20% in soy group versus 18% in placebo group (P value not given) |
| Radhakrishnan 2009 |
100 |
Soy sachets (25 mg isoflavone soy protein isolate containing 75 mg isoflavones in powder form) |
Placebo powder |
6 months |
Acceptability of treatment according to taste, odor or bulk of preparation |
Not reported |
