Table 2.
Instruments for each studied cytokine in the cis-pQTL and cis-eQTL analyses.
| cis-pQTL | cis-eQTL | ||||||
|---|---|---|---|---|---|---|---|
| Cytokine | Gene | No. SNPs | R2 | F-statistic | No. SNPs | R2 | F-statistic |
| activePAI | SERPINE1 | 1 | 0.003 | 16 | – | – | |
| bNGF | NGF | – | – | 1 | 0.002 | 7 | |
| CTACK | CCL27 | 3 | 0.060 | 75 | 2 | 0.041 | 77 |
| Eotaxin | CCL11 | 6 | 0.015 | 29 | 4 | 0.010 | 30 |
| FGFBasic | FGF2 | – | – | 2 | 0.002 | 8 | |
| GROa | CXCL1 | 11 | 0.272 | 186 | 1 | 0.127 | 993 |
| HGF | HGF | 6 | 0.010 | 19 | – | – | |
| IL-16 | IL16 | 18 | 0.037 | 44 | 6 | 0.031 | 114 |
| IL-18 | IL18 | 5 | 0.051 | 71 | 2 | 0.024 | 86 |
| IL-1a | IL1A | – | – | 3 | 0.003 | 5 | |
| IL-1ra | IL1RN | 18 | 0.075 | 79 | 2 | 0.017 | 165 |
| IL-2ra | IL2RA | 14 | 0.260 | 72 | 4 | 0.130 | 128 |
| IL-6 | IL6 | 1 | 0.002 | 16 | 1 | 0.001 | 8 |
| IL-7 | IL7 | 1 | 0.005 | 16 | – | – | |
| IL-8 | CXCL8 | 1 | 0.004 | 72 | 2 | 0.005 | 41 |
| IL-12p70 | IL12A | 1 | 0.002 | – | – | ||
| IL-12p70 | IL12B | 1 | 0.002 | – | – | ||
| IP-10 | CXCL10 | 5 | 0.020 | 35 | – | – | |
| MCP-1 | CCL2 | 28 | 0.006 | 4 | 3 | 0.001 | 8 |
| MCP-3 | CCL7 | 13 | 0.289 | 77 | – | – | |
| MCSF | CSF1 | 13 | 0.049 | 62 | 3 | 0.018 | 93 |
| MIF | MIF | 2 | 0.019 | 34 | 5 | 0.020 | 14 |
| MIG | CXCL9 | 1 | 0.011 | 41 | 2 | 0.008 | 15 |
| MIP1a | CCL3 | 34 | 0.217 | 111 | 1 | 0.059 | 1194 |
| MIP1b | CCL4 | 26 | 0.147 | 67 | 3 | 0.003 | 12 |
| PDGFbb | PDGFB | 1 | 0.001 | 18 | – | – | |
| RANTES | CCL5 | 1 | 0.009 | 31 | 1 | 0.009 | 31 |
| SCF | KITLG | 3 | 0.006 | 30 | 2 | 0.001 | 7 |
| SCGFb | CLEC11A | 2 | 0.016 | 57 | 1 | 0.004 | 28 |
| SeSelectin | SELE | 2 | 0.008 | 91 | 2 | 0.002 | 7 |
| sICAM | ICAM1 | 25 | 0.168 | 35 | 2 | 0.004 | 11 |
| sVCAM | VCAM1 | 1 | 0.003 | 16 | 1 | 0.003 | 16 |
| TNF-A | TNF | 2 | 0.004 | 19 | – | – | |
| TNF-B | LTA | – | – | 1 | 0.001 | 5 | |
| TRAIL | TNFSF10 | 46 | 0.027 | 7 | 5 | 0.006 | 14 |
| VEGF | VEGFA | 21 | 0.073 | 105 | 1 | 0.0004 | 10 |
activePAI, active plasminogen activator inhibitor-1; bNGF, beta nerve growth factor; CTACK, cutaneous T-cell attracting chemokine; FGFBasic, basic fibroblast growth factor; GROa, growth-regulated oncogene-alpha; HGF, hepatocyte growth factor; IL, interleukin; ra, receptor antagonist; IP-10, interferon gamma-induced protein 10; MCP-1, monocyte chemotactic protein-1; MCP-3, monocyte chemotactic protein-3; MCSF, macrophage colony-stimulating factor; MIF, macrophage migration inhibitory factor; MIG, monokine induced by interferon-gamma; MIP, macrophage inflammatory protein; PDGFbb, platelet-derived growth factor BB; SCF, stem cell factor; SCGFb, stem cell growth factor beta,; SeSelectin, soluble E-selectin; sICAM, soluble intercellular adhesion molecule; sVCAM, soluble vascular cell adhesion molecule; TNF, tumour necrosis factor; TRAIL, TNF-related apoptosis inducing ligand; VEGF, vascular endothelial growth factor.