Fig. 2.

Pathology and immunohistochemical staining A. Deep Aggressive angiomyxoma: (H&E) Hematoxylin and eosin stain showing the lesion with dilated lymphatics and entrapped fat; (Desmin) Desmin staining diffusely positive in stromal cells; (ER) Estrogen receptor is diffusely positive in the stromal cells; (SMA) Smooth muscle actin highlights the perivascular smooth muscle while negative in the stromal cells. B. Superficial angiomyxoma: (H&E) Hematoxylin and eosin stain demonstrating a well-circumscribed spindle cell proliferation with a prominent myxoid stroma, numerous small blood vessels, and clear margins of excision; (Desmin) Desmin staining negative in stromal cells; (Alcian Blue) Alcian blue PAS, Periodic Acid Schiff, strongly positive for mucin; (S-100) S-100 staining negative. (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)