Fig. 2.

Increased osteoclast activity in ERI-treated mice. A. Representative sections of the lumbar vertebrae collected from VCL- (left panels) and ERI- (right panels) treated mice. The right sections in each group show the high-magnification images of the boxed area in the left sections. The bone surface is artificially outlined by black lines for better visualization. Bars, 250 μm. B. Structural indices, osteoclast indices, osteoblast indices, and MAR of VCL-, ERI-, and DOX-treated mice analyzed by histomorphometric analysis. Five mice per each treatment group were analyzed. *, P < 0.05; **, P < 0.01; ***, P < 0.001; ****, P < 0.0001 (compared with those in the VCL-treated group).