Table 1.

Summary of MT binding and tau aggregation for different tau mutations in the 0N3R and 0N4R isoforms for in vivo and cell-based studies.

Tau mutations	0N4R MT binding	0N3R MT binding	0N4R Tau aggregation	0N3R Tau aggregation
G335V	↓ (Xia et al., 2019)	↓*	↑ (Xia et al., 2019)	↔*
S352L	↓ (Xia et al., 2019)	↔*	↔ (Xia et al., 2019)	↔*
S356T	↓ (Xia et al., 2019)	↑*	↑ (Xia et al., 2019)	↑↑*
V363I	↓ (Xia et al., 2019)	↑*	↑ (Morelli et al., 2018; Xia et al., 2019)	↑*
V363A	↓ (Xia et al., 2019)	↔*	↔ or ↑ (Morelli et al., 2018; Xia et al., 2019)	↔*
G366R	↓ (Xia et al., 2019)	↓*	↔ (Xia et al., 2019)	↑*

Asterisk (*) represents results of the current study.